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How do they do that? They do cardiovascular exercises on empty stomach; they eat a large breakfast; they eat a large lunch; and they eat minimal calories, just proteins and vegetables in the evening. So the bottom line — there are many studies here. Somebody wants to know how you feel about eating three times a day versus five.

I say that because eating is pro-inflammatory. In Ayurvedic medicine — some practitioners there are very versed on that. What do you think, Bettina? Bettina Newman: I think the constitution of the meals is important. I would definitely agree. Another huge lesson is poor sleep hygiene. They would barely sleep and have sleep hacking. They want a CPAP machine, they have to sleep in different rooms from their spouses because they snore, and all these different things.

That sucks. Sleep is huge. This is the latest thing in metabolic science and obesity — the circadian clock genes and all that. It sounds kind of voodoo to think that there are molecular clocks inside our cells, but it really makes sense. Why do you want to do an adrenal salivary index first thing in the morning? So, getting them back on track — turning out the lights at night and measuring melatonin, getting regular consistent sleep.

Sleep is very, very, very important — not just for body composition, but for detoxification, for hormone balance, for neurologic function, for cardiovascular function. But this circadian clock system, I just want you all to know, is very, very real. This has been validated, and from the clinical standpoint, we need to start being conscious enough and talk about not only meal timing, nutrient timing, but also supplement timing.

Individuals become more insulin-resistant as the day progresses. So, this is huge. Yeah, support their adrenals. You can give them ashwagandha or whatever else, but we also need to get them back into rhythm — get them sleep in consistent times, get them corrected with melatonin. Their clocks are these maestros, metabolic maestros.

They do so much and all that. I want to talk about this slide — just this illustration from an article here. Incidentally, we actually burn fat most effectively at night. Conversely, your blood sugar supportive agents would most likely be best administered in the afternoon and the later part of the evening when we become more insulin-resistant.

Also, exercise. This is very, very important. My wife and I recently moved. I never slept well there. I always felt tired when I woke up and not restful, just kind of out of it and made a coffee. We both sleep 8 hours no problem. Whenever I wake up, I feel amazing. We want it that dark; we want it black.

You should have eaten most of your calories during the day. So, that food is going to spend a lot of time interacting with your gut microflora. So, this is really something that we need to consider. We talked about the microflora a lot of times, but we always need to keep in mind how the things that we eat influence the gut microflora. Coincidentally, the benefits of bacteria of the world and other beneficial gut bacteria have the enzymatic capacity to break them down.

So, in addition to probiotics, in addition to prebiotics and immunoglobulin-rich colostrum, and all these things, the polyphenols are huge for supporting homeostasis in the GI tract. I know Bettina — you probably recommend this — but you want your plate like a rainbow.

The mechanism of action is really improving the composition of the gut microflora. This is some great pictures that I took while in Korea in November. Like I said, with every meal — we had kimchi before and after — and polyphenol-like rich fruits, fermented vegetables; the rice that we ate was colored rice. It was amazing. Again, there was very little of any overweight people. The gut microflora link with dysmetabolism, with obesity is slightly more complicated than just the fermentation that I was talking to you about and just the selective proliferation and selective growth of good and bad bacteria.

So, a high-phytochemical, high-fiber, plant-based diet with some lean protein and good healthy fats is a low endotoxin diet. Belly Fat Effect: The Real Secret About How Your Diet, Intestinal Health, and Gut Bacteria Help You Burn Fat Basically, this is just an appendage that resides on the cell membrane of different bacteria — gram-negative type bacteria, which include e-coli and a couple of others — these guys are very pro-inflammatory — so the huge lesson is get people into a low endotoxin diet.

I bring this up because I want you all to look at blood lipids and to look at blood glucose. So, instead of that just major reaction, we need chromium or vanadium or whatever it is. So, instead of just driving down those lipids with pharmacologic agents, even though those agents may have additional health properties, we should also be looking at the diet in the gut. So instead of, again, using pharmacologic agents, nutraceuticals agents, we need to get to the source of the problem, and the source of the problem is probably gut bacteria imbalances and gut permeability, gut immune imbalances.

So instead of looking at this major reaction of the postprandial effects, we have a colorful three-dimensional model of how diet interacts with our intestinal barrier, with our gut microflora, and then affects systemic metabolic parameters from fat burning, insulin resistance, and so on.

The best clinical tools — how can you modulate this as a practitioner or in your own life? They also incidentally can downregulate gram-negative bacteria. But this is a whey protein colostrum. I put pumpkin seeds here twice maybe because I like them so much. Pumpkin seeds can liberate alkaline phosphatase from the gut.

Alkaline phosphatase helps to break down endotoxin. Supporting the gut barrier — you guys already know this. So again, just going after calories, just going after chromium, vanadium, and green coffee bean extracts is a wrong approach. A key to this is tolerance at barriers. In the context of atopy and even autism and various things, but this is huge from metabolic challenges as well. You need to be insulin-sensitive, so we need to calm down the inflammation.

One of the best ways to modulate this — one of the best molecules I should suggest to target is leptin. But really, what I want to give you guys an option to learn more about leptin, to learn more about how it modulates the immune system, I made a minute video all on leptin — I mean literally we went to like 60 studies on that, and I can send that to you.

No one, to my knowledge, is talking about leptin in this way. I think a lot of practitioners can benefit from this; a lot of patients can benefit if they understand this. You can read the book, too. I really apologize for the technical issues, and I had no idea. I was just sitting here talking to myself and Bettina had to call me. I apologize about that.

We have about 65 questions here and a couple of people have their hand raised, so we want to get to those folks. Bettina, thank you for your great commentary. I really do appreciate that — all your support and all you do for us, so thank you. My pleasure.

Thank you. Mike Mutzel: For the folks that have their hands raised, maybe we can get to their questions first and then address maybe some of the questions that are out there. You show me how to get to those people. Mike Mutzel: Jeff, do you have a question? Jeff: Yeah, I have submitted it. Mike Mutzel: Yes. They're very active working and walking. At least, this is just from limited my observation of South Korea. I think rice is not necessarily a staple.

Jeff: Thanks. The segment comprised 65 percent of net sales last year. The filing did not reveal how many shares the company planned to sell or their expected price. The company also did not disclose the ticker symbol and exchange it planned to list its shares on. The amount of money a company says it plans to raise in its first IPO filing is used to calculate the registration fees. The final size of the IPO could be different.

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